The following effects can occur in the treatment area during and after a
treatment. These effects are temporary and generally resolve within days or
During a treatment:
• Sensations of pulling, tugging, and mild pinching at the treatment site.
• Intense cold, tingling, stinging, aching, cramping. These sensations
subside as the area becomes numb.
Immediately after a treatment:
• Redness and firmness.
• Transient blanching and/or mild bruising around the edges of the
• Tingling and stinging.
One to two weeks after a treatment:
• Redness, bruising, and swelling.
• Tenderness, cramping, and aching.
• Itching, skin sensitivity, tingling, and numbness. Numbness can persist up
to several weeks after a treatment.
• Sensation of fullness in the back of the throat after submental area
There are other side effects that can occur with submental area treatments:
• Cold exposure to the hypoglossal nerve may cause tongue deviation
following treatment of the submental area.
• Cold exposure to the marginal mandibular nerve may cause lower lip
weakness following treatment of the submental area.
• Cold exposure to the submandibular gland may cause dry mouth, or
decrease in saliva production, following treatment of the submental area.
Are there any other possible side effects that can occur?
There are some rare side effects that have been seen both in clinical studies
and commercial use:
• Paradoxical hyperplasia: Visibly enlarged tissue volume within the
treatment area, which may develop two to five months after treatment,
possibly even after a visible result is noticed. Surgical intervention is
required for correction may be required.
• Late-onset pain: A typical onset several days after a treatment and
resolution within several weeks.